Elevation of GPRC5A expression in colorectal cancer promotes tumor progression through VNN‐1 induced oxidative stress

Oxidative Stress and Tumor Progression in Colorectal Cancer Running title: Oxidative stress in colorectal cancer

Oxidative stress and tumor progression in colorectal cancer.

BACKGROUND/AIMS Elevated oxidative status has been found in many types of cancer cells. Recent studies have shown that the enzymatic product of thymidine phosphorylase (TP) generated reactive oxygen species (ROS) within cancer cells. The aim of this study was thus to evaluate the signal transduction pathway and the role of ROS in colorectal cancer. METHODOLOGY Blood specimens were obtained fr...

Study of FGF14 gene expression and cancer progression in colorectal cancer tissue samples

Background: Colorectal cancer is one of the main causes of cancer death and the third most common malignant cancer worldwide. FGF14 is a member of the large family of fibroblast growth factors. These factors control a wide range of biological functions, including cell proliferation, survival, migration and differentiation that disturbing their expression can lead to cancer. The purpose of this ...

Overexpression of paxillin induced by miR-137 suppression promotes tumor progression and metastasis in colorectal cancer

The deregulation of paxillin (PXN) has been involved in the progression and metastasis of different malignancies including colorectal cancer (CRC). miR-137 is frequently suppressed in CRC. PXN is predicted to be a direct target of miR-137 in CRC cells. On this basis, we hypothesized that overexpression of PXN induced by suppression of miR-137 may promote tumor progression and metastasis and pre...

Evaluation of MLL2 (KMT2B) Gene Expression in Colorectal Cancer Tissue Compared with Adjacent Tumor Free Tissue

Background and Aims: An impairment of expression in MLL2 gene involved in histone methylation induces alteration in the methylation patterns at enhancers and causes several cancers including colon cancer. In this study, MLL2 expression was evaluated in North West of Iran. Materials and Methods: To evaluate the MLL2 expression in patients with colon cancer, 25 tumor samples and 25 samples of tu...